Axoplasmic transport of a brain-specific soluble protein☆
نویسندگان
چکیده
منابع مشابه
Axoplasmic transport of a brain-specific soluble protein.
The rate and extent of axoplasmic transport of the brain-specific soluble protein (14-3-2 protein) has been investigated in the avian visual system. 1-day-old chicks were injected monocularly with tritiated proline, Incorporation of the isotope into the 14-3-2 protein synthesized within the retina of the injected eye, as well as the appearance of the labeled protein in the optic lobes was deter...
متن کاملSlow axoplasmic transport under scrutiny.
The origin of axoplasmic proteins is central for the biology of axons. For over fifty years axons have been considered unable to synthesize proteins and that cell bodies supply them with proteins by a slow transport mechanism. To allow for prolonged transport times, proteins were assumed to be stable, i.e., not degraded in axons. These are now textbook notions that configure the slow transport ...
متن کاملMicrotubules and axoplasmic transport. Inhibition of transport by podophyllotoxin: an interaction with microtubule protein
Pharmacological evidence is presented for the involvement of microtubules in the process of fast axoplasmic transport. A quantitative measure of the inhibition of axoplasmic transport in an in vitro preparation of rat sciatic nerve is described. The alkaloids colchicine, podophyllotoxin, and vinblastine, which are known both to disrupt microtubules and to bind to the protein subunit of microtub...
متن کاملPosttranslational modification of a neurofilament protein during axoplasmic transport: implications for regional specialization of CNS axons
The possibility that proteins are modified during axoplasmic transport in central nervous system axons was examined by analyzing neurofilament proteins (200,000, 140,000, and 70,000 mol wt) along the mouse primary optic pathway (optic nerve and optic tract). The major neurofilament proteins (NFPs) exhibited considerable microheterogeneity. At least three forms of the " 140,000" neurofilament pr...
متن کاملAxoplasmic Transport in the Crayfish Nerve Cord
Axoplasmic proteins in the crayfish nerve cord were labeled by the incorporation of high specific activity (3)H-leucine that was injected into one of the abdominal ganglia. The labeled proteins moved caudad as a sharply defined peak at 1.1 mm/day. The level of radioactivity in the cord decreased slowly as the peak approached the tail. From the sharpness of the peak and the low decrement of labe...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - General Subjects
سال: 1975
ISSN: 0304-4165
DOI: 10.1016/0304-4165(75)90167-1